Ella Purnell (Lucy MacLean)
Lucy is the main character, a woman from Vault 33 who sets out into the wasteland after leaving her vault. Survival and discovery are her journey.
Aaron Moten (Maximus)
Maximus is a member of the Brotherhood of Steel, using his strength and skills to navigate the dangers of the wasteland.
Walton Goggins (Cooper Howard)
Cooper, also known as The Ghoul, is a survivor of the Great War turned bounty hunter, armed to the teeth and living in the wasteland for over 200 years.
Kyle MacLachlan (Hank MacLean)
Hank is Lucy's father and the overseer of Vault 33, described as a benevolent leader.
Xelia Mendes-Jones (Dane)
Dane is an initiate of the Brotherhood of Steel, aspiring to become a fully-fledged knight and a friend to Maximus.
Mike Doyle (Mr. Spencer)
Mr. Spencer's role is not detailed much, leaving some mystery about his character.
Moises Arias (Norm MacLean)
Norm is Lucy's brother, not as enthusiastic about Vault 33 as others.
Johnny Pemberton (Thaddeus)
Thaddeus is a bully within the Brotherhood of Steel, particularly targeting Maximus.
Cherien Dabis (Birdie)
Birdie's character is not extensively described, adding an element of intrigue.
Dale Dickey (Ma June)
Ma June is a trader from Filly with a rough temperament and a penchant for violence.
Matty Cardarople (Huey)
Huey's character details are sparse.
Sarita Choudhury (Moldaver)
Moldaver is a mysterious and morally ambiguous character in the wasteland.
Michael Emerson (Siggi Wilzig)
Siggi is a mysterious person Lucy meets during her travels.
Chris Parnell (Ben)
Ben is the one-eyed overseer of Vault 32, providing comedic relief.
Frances Turner (Barb Howard)
Before the big war, Barb was married to Cooper. This might impect how Cooper acts and feels in the story.
Teagan Meredith (Janey Howard)
Janey is Cooper's daughter, with her fate in the wasteland uncertain.
Dave Register (Chet)
Chet is attracted to Lucy despite being cousins, and he's Norm's best friend.
Leslie Uggams (Betty Pearson)
Betty is a member and leader of Vault 33's governing council, focused on the vault's safety.
Zach Cherry (Woody Thomas)
Woody is another member of Vault 33's governing council, described as inexperienced and naive.
Rodrigo Luzzi (Reg McPhee)
Reg is also on Vault 33's governing council, putting his own interests first.
Annabel O'Hagan (Steph)
Steph is Lucy's best friend and an active member of Vault 33, pregnant during the events of the series.
Matt Berry (Mr. Handy)
Mr. Handy is a RobCo robot encountered by Lucy in the wasteland, voiced by Matt Berry.
In a future post-apocalyptic Los Angeles brought about by nuclear decimation, citizens must live in underground bunkers to protect themselves from radiation mutants and bandits. The beginning of the nuclear fallout begins in 2077, but it looks and feels way more like the 1950s.
Lucy (Ella Purnell) who is our main cast is a vault dweller. She's grown up underground in an impenetrable Vault, or maybe a bunker, to shield her and those with her from the radiation on the surface. Because of an incident, Lucy leaves the Vault and travels to the surface.